The CaSB major consists of a methodology core (7 courses: 27 units) and a concentration/track (min. 5 courses: 20 units). Effective 22W, all students admitted to the major will be held to the new track curriculum. Students admitted to the major (not the pre-major) prior to 22W have the option to remain on the previous concentration curriculum.

CaSB Major Sheet

Please reference the CaSB Major Sheet for major course requirements, track information, and department policies, including information on how to graduate with honors.

NOTE: The CaSB Major Sheet – Track Curriculum is reflective of requirements effective Winter 2022 and forward.  For all students admitted to the major prior to Winter 2022, please consult the CaSB Major Sheet – Concentration Curriculum, your Degree Audit Report, and the CaSB Departmental Counselor for your major requirements.

Computational & Systems Biology (CaSB) Major Methodology Core Upper Division Requirements (Effective Fall 2021)

Gateway I: C&S BIO/COM SCI/BIOENGR M184 (2 Units, Graded Pass/No Pass)
Gateway II: C&S BIO/COM SCI 185 (4 Units)
Probability: STATS 100A OR MATH 170E OR EC ENGR 131A (4 Units)
Statistics: STATS 100B OR BIOSTATS 100A (4 Units)
Biological Modeling: C&S BIO M150 (5 Units)
Capstone Series (2 courses, pick one option)**:

Option 1: C&S BIO 199 (4 Units) and C&S BIO M187 (4 Units)

Option 2: C&S BIO 198A (4 Units) and C&S BIO 198B (4 Units)

Option 3: C&S BIO 195 (4 Units) and C&S BIO M187 (4 Units)

**Students admitted to the major (not the pre-major) prior to Fall 2020 are required to complete just one course: C&S BIO M187.

Tracks

IMPORTANT: Effective 22W and forward, the previous concentration curriculum has been replaced with tracks. For students admitted to the major (not the pre-major) before 22W, info on the concentration curriculum can be found here.

1 Course from COM SCI CM121; COM SCI CM122; COM SCI CM124

2 Courses from COM SCI CM121; COM SCI CM122; COM SCI CM124; EE BIOL C135; MCD BIO CM156; MCD BIO 187AL; PHYSCI 125; STATS M254

2 Courses from list of Life Science courses 

More info on the Bioinformatics track can be found here.

3 Courses from COM SCI CM124 OR COM SCI M226; COM SCI M146 OR STATS C161 OR MATH 156; COM SCI 161; COM SCI 168; COM SCI 180 OR MATH 182; EC ENGR C143A; EC ENGR C147; MATH 155; MATH 164; STATS 101A; STATS 101C

At most two courses may be from Mathematics

2 Courses from list of Life Science courses 

More info on the Biological Data Sciences track can be found here.

3 Courses from C&S BIO M186 OR COM SCI M182; EC ENGR 102; EC ENGR 113; EE BIOL C119A; EE BIOL C119B; MATH 134 OR MATH 135; MATH 136; MATH 142; MATH 146; MATH 168; MATH 171

At most two courses may be from Mathematics

2 Courses from list of Life Science courses 

More info on the Dynamical Modeling track can be found here.

Students also have the option to pursue a Customized track.

Capstone Research

As part of the Capstone requirement, students are expected to complete, at minimum, 2 quarters of research or similar internship project experience supervised by a UCLA faculty member while taking their Capstone courses. Students are advised, however, to start early, ideally in their junior year. It is recommended that students complete at least a year (or more) of research/project experience by the time they complete their second Capstone course. This helps ensure that students have sufficient material for their senior thesis. Please see the following pages for additional information:

Capstone Courses & Research Expectations

Major Methodology Core Course Planning

The Gateway and Capstone courses that are part of the Major Methodology Core are only offered in certain quarters and are designed to be taken in a certain sequence. Students are advised to take C&S BIO M184 (Fall), 185 (Winter), and M150 (Spring) in their 2nd or 3rd year. Students are advised to take their two Capstone courses during their 4th year, though a few students may take them in their 3rd year. C&S BIO M187 is typically offered in Spring quarter.

The timeline below illustrates the advised order of courses and research expectations.


When planning major coursework, students must be mindful of pre-requisites. Some courses required for the CaSB major and its concentrations have additional pre-requisites that are not part of the CaSB major or pre-major curriculum.

The flowcharts below are meant to help students plan out major coursework by depicting the requisites for each methodology core requirement. These flowcharts were last updated September 2021. Always check the Registrar’s Course Descriptions for the most up-to-date requisites.


Additionally, students must be mindful of when classes are offered (i.e., which quarters). CaSB compiles a tentative list of upper-division course offerings prior to each academic year. This list is tentative and subject to change by the departments offering each course. Students should check the Schedule of Classes or with respective departments for the most up-to-date course offerings.

Tentative Schedule of Upper-Division Course Offering AY 21-21 (last updated June 2021)

It is recommended that students meet with their Departmental Counselor regularly to plan out major coursework.

Other Important Information

All major courses must be taken for a letter grade, C or better, with the exception of C&S BIO/COM SCI/BIOENGR M184 which is only offered on a Pass/No Pass basis.^
^CaSB made a temporary exception allowing pre-major courses taken between Spring 2020 and Summer 2021 to be taken for a Pass grade. More details on this exception can be found here.

Students must have a minimum 2.0 GPA in upper-division major coursework to graduate.

Students who receive a C- or below in a major course must either repeat the course or petition to have the lower grade count for the major. More information on petitioning can be found here.

Students are subject to any requirement changes in the major until they are officially admitted to the major.